The trial is based on a study at Brigham and Women's Hospital in Boston that found that a nightly tablet combining two non-sleep drugs could stop snoring.
According to SleepEducation, over 40% of men and 24% of women in America snore on a daily basis, meaning nearly one-third of the country lives with a partner, parent, or roommate who snore and disrupt sleep. Luckily, it can now be a thing of the past if a new promising drug entering clinical trials turns out to be successful. The trial is based on a 2018 study at Brigham and Women's Hospital in Boston which found that a nightly tablet which combined two non-sleep drugs, reduced the snoring of 20 participating volunteers by 74% - from an average of 28.5 breathing interruptions per hour to just 7.5, reports New York Post.
And now, two years on from the study, researchers have banded together to find a potential therapy to the recurring problem millions are facing. As per reports, the trial is being sponsored by Apnimed, a company based out of Cambridge, Massachusetts, which has taken the 2018 study towards execution. Snoring, as a condition, occurs when facial muscles relax during sleep, which leads to a narrow opening for air to pass through for breathing. The rattling sound we typically hear comes from the mouth's soft tissues vibrating when air forces itself in. While snoring is quite common, over 22 million people in the US suffer from a condition that deprives them of oxygen levels in a condition called Obstructive Sleep Apnea. People who suffer from the condition are said to be over 40, overweight, or are heavy drinkers.
For people with OSA, there were only two methods to attain uninterrupted sleep — a complete lifestyle change including weight loss and side-sleeping. And if that doesn't help, they would have to use a breathing device otherwise known as continuous positive airway pressure machine or CPAP to control oxygen levels. This device requires sleepers to wear a mask that is connected to a humidifier tank that circulates the air by keeping one's throat open. The new drug however can reduce all the complicated stuff with just a single pill. Currently code-named AD109, the tablet contains two existing medications - Atomoxetine and Oxybutynin. The former has been used extensively for close to 20 years to treat kids with ADHD while the latter is usually prescribed to treat the loss of bladder control.
The pill to stop snoring: Once-a-night tablet eases the symptoms of sleep apnoea https://t.co/ooMxZo4OnY— Daily Mail US (@DailyMail) October 27, 2020
The unique drug was arrived upon after researchers found that it reduces snoring in patients while increasing blood oxygen levels as evidenced over the course of the trial. However, there could be some side-effects to the new treatment which can have both physical and mental consequences. For instance, Oxybutynin is known to cause abdominal discomfort or constipation while Atomoxetine is associated with suicidal thoughts and mood swings. Speaking to Daily Mail, Neil Stanley, an independent sleep expert who's following the trial closely calls the findings 'promising'. "These are interesting preliminary findings, and the reduction in symptoms is very promising. But more research is needed to see if the effect is sustained."
If it's dual purpose and helps you fall asleep sign me up— Anti-Femi 🏳️🌈 (@AntiFlemi) October 27, 2020